251 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

    Sudipta Mondal, Priyadarshan Kinatukara ... Rajan Sankaranarayanan
    DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.
    1. Biochemistry and Chemical Biology

    Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

    Tomomi Hashidate-Yoshida, Takeshi Harayama ... Takao Shimizu
    LPCAT3 incorporates arachidonic acid into membrane phospholipids, which promotes lipoprotein assembly by enabling triacylgylcerols to cluster in the membrane.
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley, Venkateshwari Varadharajan ... J Mark Brown
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Medicine

    Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes

    Mi Lai, Dana Al Rijjal ... Michael B Wheeler
    Lipid dysmetabolism occurs at postpartum in women who progress from GDM to type 2 diabetes, and specific lipids could predict the progression.
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Structural Biology and Molecular Biophysics

    Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

    Jeffrey S Iwig, Yvonne Vercoulen ... John Kuriyan
    A key activator of Ras signaling adopts an autoinhibited, dimeric conformation that is activated by membrane and calcium binding.
    1. Cell Biology

    TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

    Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
    TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
    1. Epidemiology and Global Health
    2. Medicine

    Ontogeny of circulating lipid metabolism in pregnancy and early childhood – a longitudinal population study

    Satvika Burugupalli, Adam Alexander T Smith ... Barwon Infant Study Investigator team
    Plasma lipidomic profiling in pregnancy, infancy and early childhood provides a framework to define the relationship between lipid metabolism and health outcomes in early childhood.
    1. Ecology

    Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by ‘Candidatus Liberibacter asiaticus’

    Jiayun Li, Paul Holford ... Xiaoge Nian
    Molecular mechanism that Candidatus Liberibacter asiaticus improves the lipid metabolism and fecundity of Diaphorina citri through adipokinetic hormone and its receptor.
    1. Microbiology and Infectious Disease

    Lipid hijacking: A unifying theme in vector-borne diseases

    Anya J O'Neal, L Rainer Butler ... Joao HF Pedra
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.

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