Browse our latest Biochemistry and Chemical Biology articles

Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.

A small brain-derived lipid prevents bristle worms from entering maturation and death, challenging current views of hormone evolution and pesticide specificity.

Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.

Cholesterol regulates cell-cell communication by activating the Hedgehog pathway, a central signaling system in development, regeneration and cancer.

Quantitative binding and kinetic assays on DNA polymerases η and δ define the mechanism for polymerase exchange during human translesion DNA synthesis across a UV-induced lesion on the lagging strand.

A protein regulator of alternative pre-mRNA splicing arrests spliceosome assembly at a previously unrecognized step that defines new intermediate stages in the formation of exon complexes.

Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.

The first de novo synthesis of polyisoprenoids correspond to natural rubber in vitro with the recombinant proteins is achieved by identification and cell-free translation-coupled reconstitution of the rubber biosynthetic machinery on rubber particles.

The multipronged chemical biology approach unraveled a novel mechanism by which mTOR is regulated by the second messenger calcium.