Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    DEER of Singly Labelled Proteins to Evaluate Supramolecular Packing of Amyloid Fibrils

    Karen Tsay, Asif Equbal ... Yann Fichou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

    Xiaoyu Yu, Yuanjun He ... Douglas J Kojetin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Modulating inter-mitochondrial contacts to increase membrane potential for mitigating blue light damage

    Yuxin Wang, Kangqiang Qiu ... Jiajie Diao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system

    Xiaofei Ge, Zhiwei Gu, Jiawei Wang
    High‑resolution cryo‑EM structures uncover YbjP as a novel lipoprotein that positions TolC and supports conformational changes in E. coli drug efflux pumps mediating antibiotic resistance.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A lipoprotein partner for the Escherichia coli outer membrane protein TolC

    Jim Horne, Elise Kaplan ... Ben F Luisi
    Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

    Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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Highlights

    1. Structural Biology and Molecular Biophysics

    One enzyme, two substrates

    Ana S Ramírez, Camilo Perez
    1. Structural Biology and Molecular Biophysics

    Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors