Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Navigating contradictions in enteric chemotactic stimuli

    Kailie Franco, Zealon Gentry-Lear ... Arden Baylink
    Motile Enterobacteriaceae override chemorepulsion from the microbiota metabolite indole in favor of nutrient attraction, challenging the idea that indole taxis protects the host against intestinal infection.
    1. Structural Biology and Molecular Biophysics

    Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove

    Christina Alexandra Stephens, Niek van Hilten ... Michael Grabe
    The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca2+ activation, but limited scrambling also occurs in the dimer interface independent of Ca2+.
    1. Structural Biology and Molecular Biophysics

    Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

    Adrián Merino-Salomón, Jonathan Schneider ... Germán Rivas
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the E. coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

    Binnu Gangadharan, Daniel L Kober, Luke M Rice
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryo-EM and MD simulations

    Jordan M Mancl, Xiaoyang Wu ... Wei-Jen Tang
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

    Zeming Qiu, Wei Wang ... Sanduo Zheng
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Interpretable protein-DNA interactions captured by structure-sequence optimization

    Yafan Zhang, Irene Silvernail ... Xingcheng Lin
    A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.
    1. Structural Biology and Molecular Biophysics

    Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

    Giulia Arecchi, Marica Dente ... Chiara Tesi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    Masataka Yamauchi, Giovanni B Brandani ... Shoji Takada
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
Load more

Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors