Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryoEM and MD simulations

    Jordan M Mancl, Xiaoyang Wu ... Wei-Jen Tang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase from the model microalga Chlamydomonas reinhardtii

    Théo Le Moigne, Martina Santoni ... Julien Henri
    Crystallography, molecular dynamics simulations, and biochemical analyses of Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase (SBPase) from the microalga Chlamydomonas reinhardtii identify a redox module that controls oligomeric states for the activation of the enzyme.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G-J Sterckx
    A camelid single-domain antibody potently and specifically inhibits pyruvate kinases from trypanosomatids.
    1. Structural Biology and Molecular Biophysics

    Functionally important residues from graph analysis of coevolved dynamic couplings

    Manming Xu, Sarath Chandra Dantu ... Shozeb Haider
    DyNoPy is able to deconvolute communities from complicated coevolution analysis.
    1. Structural Biology and Molecular Biophysics

    Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

    Helen B Belato, Alexa L Knight ... George P Lisi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Navigating contradictions: Salmonella Typhimurium chemotactic responses to conflicting effector stimuli

    Kailie Franco, Zealon Gentry-Lear ... Arden Baylink
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants

    Sneha Paturi, Debadutta Patra ... Mandar V Deshmukh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

    Mia L Abramsson, Robin A Corey ... Michael Landreh
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

    Assmaa Elsheikh, Camden M Driggers ... Show-Ling Shyng
    Structure-based approach identifies a KATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective KATP channel trafficking to the cell surface.
Load more

Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors