Biophysics and Structural Biology

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Decisions are made by journal editors who are active researchers in the fields of biophysics and structural biology.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry
    2. Biophysics and Structural Biology

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark et al.
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk et al.
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands

    Altaira D Dearborn et al.
    Cryo-electron microscopy and genetics show how Staphylococcus aureus pathogenicity island 1 hijacks the assembly pathway of a helper phage for its own propagation.
    1. Biochemistry
    2. Biophysics and Structural Biology

    A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

    Yvonne Vercoulen et al.
    The Ras activator RasGRP1 that impacts Ras signals in immune cells, leukemias, and colorectal cancer, switches to an active conformation aided by a pH-sensitive histidine residue in a central location of the RasGRP1 molecule.
    1. Biophysics and Structural Biology

    Molecular determinants of permeation in a fluoride-specific ion channel

    Nicholas B Last et al.
    The ion-transport pathway of an unconventional bacterial fluoride channel is mapped out through combined crystallographic and functional experiments.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    Senior Editor
  2. Arup K Chakraborty
    Arup K Chakraborty
    Senior Editor
  3. Andrea Musacchio
    Senior Editor
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