Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

    Rohan Eapen, Cynthia Okoye ... Laura S Itzhaki
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige
    Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development

    Pramila Rijal, Leiyan Wei ... Alain RM Townsend
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

    Christopher T Schafer, Raymond F Pauszek III ... David P Millar
    The conformational dynamics and landscapes of the related chemokine receptors CXCR4 and ACKR3, revealed by single-molecule analysis, provide mechanistic insights into differences in constitutive activity, ligand promiscuity, and effector coupling.
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipitò ... Christopher A Reynolds
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    ATP-release pannexin channels are gated by lysophospholipids

    Erik Henze, Russell N Burkhardt ... Toshimitsu Kawate
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

    Affiong I Oqua, Kin Chao ... Alejandra Tomas
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Sld3CBD-Cdc45 structural insights into Cdc45 recruitment for CMG complex formation

    Hao Li, Izumi Ishizaki ... Min Yao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

    Colleen A Maillie, Kiana Golden ... Marco Mravic
    Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors