Biophysics and Structural Biology

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Decisions are made by journal editors who are active researchers in the fields of biophysics and structural biology.

Latest articles

    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

    Aurèle Piazza et al.
    A combination of genetics and biophysical approaches identifies an overlapping set of sequences that form non-canonical G-quadruplex structures in vitro and induce genomic instability in cells.
    Research Article
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    1. Biophysics and Structural Biology

    Structural mechanism of ATP-independent transcription initiation by RNA polymerase I

    Yan Han et al.
    Structures of RNA polymerase I transcription machinery revealed a ratcheting motion within the complex in coordination with three distinct functional states, implicating a novel mechanism for promoter bubble opening in the absence of ATP hydrolysis.
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    1. Biophysics and Structural Biology
    2. Human Biology and Medicine

    Semen amyloids participate in spermatozoa selection and clearance

    Nadia R Roan et al
    Ex vivo characterization of the interaction of human sperm with semen factors reveals that semen amyloids, previously discovered due to their ability to enhance HIV infection, serve a physiological function by promoting disposal of the defective sperm.
    Research Article
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    1. Biophysics and Structural Biology
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
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    1. Biophysics and Structural Biology

    Model for a novel membrane envelope in a filamentous hyperthermophilic virus

    Edward H Egelman et al
    1. Biophysics and Structural Biology

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.
    Research Article
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    1. Biophysics and Structural Biology
    2. Developmental Biology and Stem Cells

    Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering

    Daniel Šmít et al
    Competition between adhesive and tensile forces regulates axon fasciculation, thus introducing a new role of mechanical tension in the development of neural networks.
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