Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

    Vikram Dalal, Brandon K Tan ... Wayland WL Cheng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Expanding automated multiconformer ligand modeling to macrocycles and fragments

    Jessica Flowers, Nathaniel Echols ... Stephanie A Wankowicz
    qFit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).
    1. Structural Biology and Molecular Biophysics

    Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

    Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble
    Understanding the dynamics of AdhE enzymes is essential to be able to control the metabolic and energy fluxes in microorganisms used to produce biofuels and biochemicals.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis

    Roya Pournejati, Jessica M Huang ... Oscar Vivas
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

    Jesse Howe, Douglas Walker ... Elisar J Barbar
    The oligomerization domain of 53BP1, a key DNA repair protein, is a trimer which binds the dimeric hub protein LC8 by a novel mechanism to form dynamic heterogeneous complexes.
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    Peter C Kroon, Fabian Grunewald ... Siewert-Jan J Marrink
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Qiang Cui
    Boston University, United States
  4. See more editors