Biophysics and Structural Biology

Biophysics and Structural Biology

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Decisions are made by journal editors who are active researchers in the fields of biophysics and structural biology.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry
    2. Biophysics and Structural Biology

    An unfolded protein-induced conformational switch activates mammalian IRE1

    G Elif Karagöz et al.
    ER-stress sensing mechanism of the unfolded protein response sensor/transducer IRE1 is conserved from yeast to mammals, where in mammals, unfolded protein binding to IRE1's ER lumenal domain is coupled to its oligomerization and activation through an allosteric conformational change.
    1. Biophysics and Structural Biology
    2. Neuroscience

    Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates

    Andrew F Mead et al.
    Vertebrate superfast muscles employ similar excitation–contraction strategies but distinct myosin heavy chain genes to allow superfast performance, revealing a maximum speed that cannot be overcome without sacrificing neural control.
    1. Biophysics and Structural Biology

    Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

    Jing Li et al.
    Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.
    1. Biophysics and Structural Biology

    Protein dynamics: Proteins acting out of (dis)order

    David Eliezer
    A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.
    Insight
    Available as:
    • HTML
    • PDF
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Nuclear microenvironments modulate transcription from low-affinity enhancers

    Albert Tsai et al.
    Efficient transcription from low-affinity enhancers is driven by nuclear microenvironments of transcription factors.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

    André Heuer et al.
    Near atomic resolution of late 40S ribosomal subunit assembly by cryo-EM reveals immature rRNA active sites stabilized by biogenesis factors.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Investigating molecular crowding within nuclear pores using polarization-PALM

    Guo Fu et al.
    The super-resolution fluorescence microscopy approach polarization PALM (p-PALM) reveals that macromolecular crowding and inhomogeneity within nuclear pores generate a structurally and dynamically complex permeability barrier.

Senior editors

  1. Arup K Chakraborty
    Arup K Chakraborty
    Senior Editor
  2. John Kuriyan
    John Kuriyan
    Senior Editor
  3. Andrea Musacchio
    Senior Editor
  4. See more editors