Biophysics and Structural Biology

Latest articles

1. 1. Biochemistry
   2. Biophysics and Structural Biology

   Ligand modulation of sidechain dynamics in a wild-type human GPCR

   Lindsay D Clark et al.

   Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
2. 1. Biophysics and Structural Biology
   2. Genes and Chromosomes

   Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

   Ramon A van der Valk et al.

   The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
3. 1. Biophysics and Structural Biology
   2. Microbiology and Infectious Disease

   Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands

   Altaira D Dearborn et al.

   Cryo-electron microscopy and genetics show how Staphylococcus aureus pathogenicity island 1 hijacks the assembly pathway of a helper phage for its own propagation.
4. 1. Biochemistry
   2. Biophysics and Structural Biology

   A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

   Yvonne Vercoulen et al.

   The Ras activator RasGRP1 that impacts Ras signals in immune cells, leukemias, and colorectal cancer, switches to an active conformation aided by a pH-sensitive histidine residue in a central location of the RasGRP1 molecule.
5. 1. Biophysics and Structural Biology

   Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

   Sojin An et al.
6. 1. Biochemistry
   2. Biophysics and Structural Biology

   Anti-diabetic drug binding site in a mammalian K_ATP channel revealed by Cryo-EM

   Gregory M Martin et al.
7. 1. Biochemistry
   2. Biophysics and Structural Biology

   Structure of RNA polymerase bound to ribosomal 30S subunit

   Gabriel Demo et al.
8. 1. Biophysics and Structural Biology

   Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

   Jing Li et al.
9. 1. Biophysics and Structural Biology

   Molecular determinants of permeation in a fluoride-specific ion channel

   Nicholas B Last et al.

   The ion-transport pathway of an unconventional bacterial fluoride channel is mapped out through combined crystallographic and functional experiments.
10. 1. Biophysics and Structural Biology

    Mechanism of activation at the selectivity filter of the KcsA K⁺ channel

    Florian T Heer et al.