Biophysics and Structural Biology

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Decisions are made by journal editors who are active researchers in the fields of biophysics and structural biology.
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Latest articles

    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

    Matthew Allan Sdano et al.
    1. Biophysics and Structural Biology

    Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system

    Sarah Schuster et al.
    Trypanosome development within the transmitting tsetse fly reveals essential adaptations of microbial motility to diverse physical microenvironments.
    1. Biophysics and Structural Biology

    The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

    Joseph Atherton et al.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

    Daniel Elnatan et al.
    A flip of the dimer asymmetry following the first ATP hydrolysis provides a mechanistic model for client remodeling by the mitochondrial Hsp90, TRAP1.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

    Johanne Le Coq et al.
    The SHIP2 inositol phosphatase is an important upstream regulator of the Akt signaling pathway, which requires a catalytic core formed by the phosphatase domain tightly packed to a C2 domain for its function.
    1. Biophysics and Structural Biology

    Acidic C-terminal domains autoregulate the RNA chaperone Hfq

    Andrew Santiago-Frangos et al.
    1. Biophysics and Structural Biology
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert et al.
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

    Nadinath B Nillegoda et al.
    The emergence of complementary electrostatic potentials after the prokaryotic-to-eukaryotic split drives physical and functional cooperation between canonical class A and class B J-proteins to boost protein disaggregation.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural insights into the light-driven auto-assembly process of the water-oxidizing Mn4CaO5-cluster in photosystem II

    Miao Zhang et al.
    The structures of photosystem II, with the water-oxidizing Mn4CaO5-cluster fully removed and in an intermediate assembly state, show that photoassembly is facilitated by perfectly pre-arranged protein ligands of the five metal ions.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells

    Lisa Seidel et al.
    Agonist and antagonist peptides of the corticotropin-releasing factor receptor type 1 adopt different folds and stabilize distinct conformations of the receptor transmembrane domain, which involves tilting of helices VI and VII around conserved glycine hinges.
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Senior editors

  1. Richard Aldrich
    Richard Aldrich
    Senior Editor
  2. John Kuriyan
    John Kuriyan
    Senior Editor
  3. Andrea Musacchio
    Max Planck Institute of Molecular Physiology, Germany
  4. See more editors