Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
Nicolas Bery, Abimael Cruz-Migoni ... Terence H Rabbitts
A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.
Combined cell labelling with a bi-cistronic reporter-gene vector and gold nanorods enables short- and long-term cell tracking in vivo via multimodal imaging (multispectral optoacoustic tomography, bioluminescence, fluorescence) with high spatial resolution.
