A novel role of the mitochondrial BKCa channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O2-independence, which is also of potential clinical relevance.
Advanced cryo-EM approaches reveal surprising insights into the molecular structure that allows nascent proteins to be inserted into the membrane of the endoplasmic reticulum.
Corey D Holman, Alexander P Sakers ... Patrick Seale
Single-cell expression profiling and genetic lineage analysis show that aging impairs adipocyte differentiation from precursor cells and blocks the thermogenic activation of adipocytes during cold exposure.
Efficient myogenic and lipogenic transdifferentiation of chicken fibroblasts in 3D culture produces meat with precisely controlled levels of intramuscular fat and extracellular matrix.
