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The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate interplay between the three different isoforms of an essential molecular motor.

A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.

Signaling specifically in cilia by a cAMP generating G-protein-coupled receptor directs tissue-specific morphogenesis.

Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.

Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.

Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.

Ecdysone-mediated regulation of Relish expression and activation in the hematopoietic niche is essential for progenitor maintenance in the Drosophila Lymph gland.

Keratins assemble into tubular filaments with a central density and exhibit structural heterogeneity, which is reflected in alterations of the helical arrangement.

Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.

Blockage of CXCL10/CXCR3 signaling between murine pancreatic precancerous lesion cells and inflammatory macrophages generates a tumor-promoting microenvironment.