Browse our latest Cell Biology articles

Page 127 of 318
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner, Abdul Naseer Malmi-Kakkada ... John B Wallingford
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Cell Biology

    Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

    Lara Katharina Krüger, Matthieu Gélin ... Phong T Tran
    During anaphase B spindle elongation, Klp9 controls the speed of both microtubule sliding and microtubule growth to coordinate the processes and thus maintain spindle stability for faithful chromosome separation.
    1. Cell Biology
    2. Medicine

    Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

    Srinu Tumpara, Matthias Ballmaier ... Sabina Janciauskiene
    Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang, Gerd Bobe ... Adrian F Gombart
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

    Michael Chas Sumner, Steven B Torrisi ... Jason H Brickner
    Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao, Danielle E Frodyma ... Robert E Lewis
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani, Sithara S Wijeratne, Radhika Subramanian
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin, Eleanor Johns ... Richard M White
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology
    2. Developmental Biology

    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

    Qian Yu, Soma Biswas ... Jing Li
    Corneal aging is regulated by the NF-κB-retinoic acid pathway and can be delayed by retinoic acid administration.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

    Christopher Duncan-Lewis, Ella Hartenian ... Britt A Glaunsinger
    Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.