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Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.

Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.

Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.

IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.

Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.

Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.

Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.

The amyloid precursor protein known for its role in causing familial Alzheimer's disease directly interacts with secreted proteins, called Wnts, known for their key roles in brain development and homeostasis, suggesting the two processes may be directly linked.

In vivo crosslinking approaches revealed that the edge-strand of Escherichia coli metallopeptidase BepA interacts with an assembly intermediate of β-barrel outer membrane protein LptD on the outer membrane protein translocon for its targeting to degradation or maturation.

HiLITR is a molecular reporter of protein localization that enables straightforward, large-scale, fluorescence-activated cell sorting-based discovery of genes that regulate complex cellular processes, such as mitochondrial and ER tail-anchored protein trafficking.