Browse our latest Cell Biology articles

Page 126 of 333
    1. Cell Biology
    2. Medicine

    Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

    Kathryn P Trogden, Justin Lee ... Irina Kaverina
    Analysis of insulin secretion patterns in pancreatic islets shows that microtubules control β-cell heterogeneity by regulating initiation and timing of secretion hot spot activity in parallel with Ca2+ signaling.
    1. Cell Biology
    2. Medicine

    An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

    Richard K Nakamura, Lee S Mann ... Bruce Reed
    Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qualified support for double-blinded models of peer review.
    1. Cell Biology
    2. Medicine

    Funding: Blinding peer review

    Michael A Taffe
    Concealing the identity of the principal investigator only partially closes the success gap between white and African American or Black researchers in NIH grant applications.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

    Braulio Bonilla, Alexander J Brown ... Kara A Bernstein
    The Shu complex enables lesion bypass of specific alkylation-induced DNA damage including abasic sites and 3-methyl-cytosine.
    1. Cell Biology
    2. Developmental Biology

    DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila

    Kristin M Sherrard, Maureen Cetera, Sally Horne-Badovinac
    Stress fibers with multiple adhesions along their lengths and treadmilling dynamics may help migrating epithelial cells maintain a linear trajectory and thereby reinforce their collective motility.
    1. Cell Biology
    2. Neuroscience

    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

    Blake A Creighton, Simone Afriyie ... Damaris N Lorenzo
    Giant ankyrin-B enables the transduction of Sema 3A repelling cues and is important for normal axonal connectivity.
    1. Cell Biology
    2. Developmental Biology

    Correct regionalization of a tissue primordium is essential for coordinated morphogenesis

    Yara E Sánchez-Corrales, Guy B Blanchard, Katja Röper
    During the morphogenesis of the tubes of the salivary glands in the fly embryo, a correct regionalization of the flat epithelial primordium by upstream transcription factors is key to drive coordinated changes in cell behavior.
    1. Cancer Biology
    2. Cell Biology

    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

    Akikazu Harada, Shinji Matsumoto ... Akira Kikuchi
    Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
    1. Cell Biology

    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

    María J Conde-Dusman, Partha N Dey ... Isabel Perez-Otaño
    Non-conventional NMDA receptors containing GluN3A subunits place constraints on the capacity of the brain to encode lasting memories through regulation of synaptic GIT1/mTOR signaling complexes.
    1. Cell Biology
    2. Immunology and Inflammation

    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

    Benedetta De Ponte Conti, Annarita Miluzio ... Sara Ricciardi
    In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.