Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
Testosterone promotes the conversion of glucose to fatty acids by increasing the expression of ACLY in seminal vesicle epithelial cells, thereby regulating the seminal plasma components.
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
Structural analysis reveals a two-step EB1-SxIP binding mechanism and identifies ligand mutations that greatly enhance affinity, offering potential therapeutic avenues for targeting microtubule plus end interactions.
