A single protein can switch cellular behaviors from protrusion to retraction based on its concentration and dynamics, revealing a novel mechanism for controlling antagonistic phenotypes in cell signaling.
A femur transplantation model of bone marrow regeneration highlights the plasticity of periosteal skeletal stem cells and their ability to contribute to bone marrow niche regeneration, ultimately facilitating hematopoietic regeneration.
For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.
Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
The SUN1-ALLAN complex serves as a nuclear envelope–spanning tether that coordinates the segregation of a bipartite microtubule organising center (MTOC) during the unusual mitosis of Plasmodium.
Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
Identification of ribosomal proteins RPS26 and RPS25, along with chaperone TSR2, as new important modifiers in the noncanonical translation process linked to fragile X premutation disorders.
AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
