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Page 19 of 330
    1. Cell Biology

    Treacle and MDC1 coordinate rDNA break repair by homologous recombination

    Andrea Haenel, Johannes Leyrer, Manuel Stucki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis

    Meagan J Makarczyk, Yiqian Zhang ... Hang Lin
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

    Akinori Endo, Chikage Takahashi ... Yukiko Yoshida
    Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.
    1. Cell Biology
    2. Developmental Biology

    Sulfation affects apical extracellular matrix organization during development of the Drosophila embryonic salivary gland tube

    J Luke Woodward, Jeffrey Matthew ... SeYeon Chung
    Sulfation is required for organizing the apical extracellular matrix during tubular organ formation.
    1. Cell Biology

    SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

    Fansen Meng, Jong Hwan Kim ... James F Martin
    A novel YAP/TEAD regulatory mechanism by NSP13 provides molecular insights into Hippo-YAP regulation after SARS-CoV-2 infection.
    1. Cell Biology
    2. Neuroscience

    Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

    Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
    Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
    1. Cell Biology
    2. Genetics and Genomics

    Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

    Yuri Fujita, Shotaro Namba ... Hisao Moriya
    A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
    1. Cell Biology
    2. Evolutionary Biology

    Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells

    Soumita Banerjee, Soniya Sanjay Shende ... Indraneel Mittra
    Uptake of cell-free chromatin particles released from dying cells and carrying non-coding DNA could redefine mammalian genomics.
    1. Cell Biology
    2. Developmental Biology

    Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem

    Sami Kilpinen, Lassi Virtanen ... Juha Partanen
    Changes of the chromatin structure suggests how the fate selector transcription factors are activated and how they guide differentiation of GABAergic and glutamatergic neurons in the anterior brainstem.
    1. Cell Biology
    2. Physiology

    Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

    Scott D Zawieja, Grace A Pea ... Michael J Davis
    Lymphatic muscle cells, but not CD34+ adventitial cells, exhibited pacemaker behaviors including pressure-dependent depolarization, pressure-dependent calcium mobilization during diastole, and propagated contraction waves induced by focal, optogenetic depolarization via channel rhodopsin2.
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