Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.
A conserved glucagon signaling pathway links high-fat diet-induced metabolic imbalance to cardiac arrhythmia through hormone-producing cells and heart-innervating neurons that regulate rhythmicity.
Distal renal tubular acidosis induced by some SLC4A1 variants is characterized by cytosolic pH alkalization, reduced ATP synthesis and defective autophagy degradative flux.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
The RNA-binding protein BICC1 can act as a genetic disease modifier for kidney cyst formation, potentially explaining the high variability of disease onset and severity in autosomal-dominant polycystic kidney disease patients.
