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    1. Cell Biology

    HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

    Hongchen Li, Xinchao Zhang ... Yanping Xu
    Functional analyses reveal the HNF4α-TET2-FBP1 axis as a critical regulator of gluconeogenesis, type 2 diabetes (T2D) progression, and metformin’s therapeutic effects, which proposes TET2 as a promising therapeutic target for T2D.
    1. Cancer Biology
    2. Cell Biology

    Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    Lucian DiPeso, Sriram Pendyala ... Emily M Hatch
    The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cell Surface Receptors: Virus attacks fish by muscling its way into cells

    Ping-Ping Liu, Zhe Wei, Xian-Wei Wang
    Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.
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    1. Cell Biology

    JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Cell Biology

    Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology
    2. Cancer Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses

    Jasmina Kerčmar, Nastja Murko ... Marjan Slak Rupnik
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology

    ACVR2A facilitates trophoblast cell invasion through TCF7/c-JUN pathway in pre-eclampsia progression

    Shujing Yang, Huanyao Liu ... Fang He
    ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental dysfunction.
    1. Cell Biology
    2. Developmental Biology

    Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

    Hyung-Seok Kim, Mary L Sanchez ... Jan L Christian
    Phosphorylation of the BMP4 prodomain is required for proteolytic activation of BMP4 homodimers, but not BMP4/7 heterodimers.
    1. Cell Biology

    Force transmission through the inner kinetochore is enhanced by centromeric DNA sequences

    Elise Miedlar, Grace E Hamilton ... Trisha N Davis
    Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
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