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Sec17 is shown to have divergent effects on pre-fusion SNARE complex activity, depending on the state of SNARE zippering and HOPS, an SM-tether complex, controls the outcome of Sec17-SNARE engagement.

Dynactin acts as an anti-catastrophe factor that extends microtubule growth; posteriorly elucidating a new essential step in oskar mRNA localisation and providing a novel mechanism by which motor-dependent transport can amplify the polarity of MT networks.

The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.

Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.

Msp1, a membrane-integral AAA ATPase at mitochondria and peroxisomes, selectively recognizes uncomplexed substrate molecules in vivo while avoiding substrates stabilized by binding partners.

Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.

Neurons use a non-canonical secretory network to deliver select proteins to postsynaptic sites in dendrites.

A signaling pathway involving PGAM5, ASK1 and JNK induces persistent FoxO activation, chaperone expression and lifespan extension following developmental mitochondrial stress, which can be blocked by mTOR signaling through GCN-2.

Super-resolution microscopy reveals the nanoscale molecular architecture of 29 protein components of a eukaryotic contractile ring relative to the membrane.

Neutrophil pseudopods are composed of multiple sheets that are inherently flat, protrude in three dimensions, and whose assembly correlates with cell turning.