Nathan A McDonald, Abigail L Lind ... Kathleen L Gould
Super-resolution microscopy reveals the nanoscale molecular architecture of 29 protein components of a eukaryotic contractile ring relative to the membrane.
Lillian K Fritz-Laylin, Megan Riel-Mehan ... R Dyche Mullins
Neutrophil pseudopods are composed of multiple sheets that are inherently flat, protrude in three dimensions, and whose assembly correlates with cell turning.
Acidification and salt, which are two major stresses caused by environmental changes, swiftly and drastically alter the microtubule system in green algae and likely many other organisms.
Genetic analyses reveal that purely quantitative changes in the relative copy number of chromosomes can be sufficient to disrupt the epigenetic mechanisms that define the cells' differentiated state.
Alexandra M Whiteley, Miguel A Prado ... Eric J Brown
Stimulation of cells with a mitochondria-depolarizing mitogen reveals a requirement for UBQLN1 expression in maintaining protein synthesis levels during cell cycle entry.
Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
Biochemical and cell biological analyses reveal that the Astrin-SKAP complex acts to stabilize kinetochore-microtubule interactions through its intrinsic microtubule binding activity and its association with the Ndc80 complex, the core component of the kinetochore-microtubule interface.
Cellular genetics highlights differences in protein catabolism in general, and the COP9 signalosome in particular, as one major source of human cellular circadian variation.
