Armaghan W Naik, Joshua D Kangas ... Robert F Murphy
In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
Maarten Hilbrant, Thorsten Horn ... Kristen A Panfilio
Late morphogenesis of the insect extraembryonic epithelia involves transient formation of a basal-basal bilayer to coordinate the functional contributions of two discrete tissues.
Jordan D Carelli, Steven G Sethofer ... Jack Taunton
An ancient complex comprising the eukaryotic elongation factor-1A and aminoacylated tRNA is shown to be the target of a cyclic heptapeptide and two unrelated natural products with potent anticancer activity.
Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.