Browse our latest Cell Biology articles

Page 61 of 324
    1. Cell Biology

    BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    Zhiwang Zhang, Qichao Liao ... Lei Zhou
    Gene function studies confirmed that the BATF-PD1 axis and BATF-IL27 axis are regulatory factor for lipid accumulation in hepatocytes and adipocytes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

    Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft
    Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

    Maikel Castellano-Pozo, Georgios Sioutas ... Enrique Martinez-Perez
    Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
    1. Cell Biology

    Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

    Marta Bicka, Corbin Black ... Dorota Wloga
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

    Aygul Subkhangulova, Miguel A Gonzalez-Lozano ... Matthijs Verhage
    SNARE protein tomosyn differentially affects two main secretory pathways in mammalian neurons.
    1. Cancer Biology
    2. Cell Biology

    EPAC1 inhibition protects the heart from doxorubicin-induced toxicity

    Marianne Mazevet, Anissa Belhadef ... Eric Morel
    The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering with its antitumoral activity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

    Yanqiu Li, Feifei Wang ... Aimin Peng
    The initiation of DNA damage checkpoint recovery involves ATM-mediated E3 ubiquitin ligase E6AP phosphorylation which disrupts E6AP-MASTL association and leads to MASTL protein accumulation and cell cycle resumption.
    1. Cancer Biology
    2. Cell Biology

    Cancer Survivorship: Protecting the heart

    Joshua M Inglis, Arduino A Mangoni
    Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.
    Version of Record
    Insight
    1. Cell Biology
    2. Developmental Biology

    Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

    Ukrae H Cho, Martin W Hetzer
    The nuclear pore complex is transiently proteolyzed during cell differentiation and the nuclear proteome experience dramatic change.
    1. Cell Biology

    Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1

    Alice M Budden, Murat Eravci ... Antony M Carr
    Rtf2 is shown to associate with multiple splicing factors and influence splicing of a subset of introns explaining why previous work erroneously assigned it as a replication restart factor in fission yeast.