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    1. Cell Biology
    2. Physics of Living Systems

    Protein Tracking: Everything, everywhere, almost at once

    Jacob Kæstel-Hansen, Nikos S Hatzakis
    A new platform that can follow the movement of individual proteins inside millions of cells in a single day will help contribute to existing knowledge of cell biology and identify new therapeutics.
    Version of Record
    Insight
    1. Cell Biology

    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner

    Tetsuya Watabe, Shinya Yamahira ... Kenta Terai
    Prostaglandin E2-mediated radial spread of PKA activation, caused by calcium transients, is a novel mode of intercellular communication in living mice.
    1. Cell Biology
    2. Developmental Biology

    Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice

    Longjie Sun, Zheng Lv ... Jiali Liu
    SRSF1 plays a critical role in posttranscriptional regulation to implement homing of precursor spermatogonial stem cells.
    1. Cell Biology

    Heparan sulfate promotes TRAIL-induced tumor cell apoptosis

    Yin Luo, Huanmeng Hao ... Ding Xu
    By binding to TRAIL and inducing its oligomerization, heparan sulfate plays a role in regulating the pro-apoptotic activity of TRAIL towards several types of tumor cells.
    1. Cell Biology
    2. Developmental Biology

    Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

    Niklas Simon, Abu Safyan ... Shinya Matsuda
    The heparan sulfate chains of the glypican Dally stabilizes morphogen Dpp on the cell surface by antagonizing receptor-mediated Dpp internalization largely independent of direct interaction with Dpp.
    1. Cell Biology
    2. Computational and Systems Biology

    Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

    Jia-Hua Qu, Khalid Chakir ... Edward G Lakatta
    Numerous pathways/function predictions were identified via gene sets, phosphopeptides, and phosphoproteins, which may point to potential novel therapeutic targets to enhance heart adaptivity, maintaining heart performance while avoiding cardiac dysfunction.
    1. Cell Biology

    Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity

    Edward M Germany, Nakajohn Thewasano ... Takuya Shiota
    Bacterial outer membrane proteins are recognized by BamD at specific signals located in multiple β-strands at the C-terminus of these proteins, and this recognition is important for efficient outer membrane protein assembly and maintaining the integrity of outer membrane.
    1. Cell Biology

    Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

    Cheng-Kuang Huang, Xianbin Yong ... Chwee Teck Lim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus

    Benjamin Seelbinder, Susan Wagner ... Moritz Kreysing
    Localized temperature gradients used as a novel method of active micro-theology that is non-invasive and probe-free, to investigate material responses of cell departments such as the different compartments of a nucleus displaying distinct material properties.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    Lutian Yao, Jiawei Lu ... Maurizio Pacifici
    Activation of Activin A-expressing progenitor cells emerges as a pivotal mechanism in bone fracture healing, shedding light on a potential therapeutic avenue to augment bone repair processes.