Browse our latest Cell Biology articles

Page 62 of 316
    1. Cell Biology
    2. Developmental Biology

    DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice

    Yi Tian Yap, Wei Li ... Zhibing Zhang
    Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.
    1. Cancer Biology
    2. Cell Biology

    Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

    Julieta Martino, Sebastián Omar Siri ... Vanesa Gottifredi
    Replication stress-indepedent synthetic lethality can be triggered in BRCA2-deficient cells by exploiting M phase defects.
    1. Cell Biology
    2. Developmental Biology

    Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish

    Kendall E Martin, Padmapriyadarshini Ravisankar ... Joshua S Waxman
    The transcription factor Nr2f1a represses ventricular and pacemaker cardiomyocyte identities within distinct regions of the zebrafish atrium.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

    Lyudmil Raykov, Manon Mottet ... Thierry Soldati
    The Dictyostelium discoideum TRAF6 homolog TrafE coordinates the autophagy and ESCRT membrane repair machineries and works in the major cell-autonomous restriction pathway to control Mycobacterium marinum intracellular infection.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

    Rafael Soares Godoy, Nicholas D Cober ... Duncan J Stewart
    Single-cell transcriptomic analysis reveals novel regenerative endothelial cell populations that mediate remarkably rapid and complete microvascular repair in a novel model of acute lung injury induced by endothelial cell ablation.
    1. Cell Biology

    Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

    Ines Hernandez-Perez, Javier Rubio ... María Isabel Geli
    Kazrin, a protein widely expressed in vertebrates whose depletion causes defects in cell adhesion and migration, is recruited to early endosomes and promotes dynein/dynactin-dependent traffic of endocytosed cargo to the recycling endosomes.
    1. Cell Biology
    2. Neuroscience

    Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor

    Domenica Ippolito, Dominique A Glauser
    A refined analysis of the mechanisms controlling CaM kinase-1 subcellular localization in sensory neurons, a cell-autonomous process known to control nociceptive plasticity and to adjust avoidance behaviors.
    1. Cell Biology

    Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

    Jonas R Knudsen, Kaspar W Persson ... Thomas Elbenhardt Jensen
    Microtubule-dependent movement of the glucose transporter GLUT4 is important for insulin-stimulated muscle glucose uptake, involves the motor protein KIF5B, and is impaired in muscle from diet-induced obese mice.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

    Hanghang Liu, Akane Wada ... Clifford J Rosen
    Loss or PTH1R-mediated repression of Zfp467 results in a pathway that increases Pth1r transcription via NFκB1 and thus cellular responsiveness to PTH/PTHrP, ultimately leading to enhanced bone formation.
    1. Cell Biology
    2. Developmental Biology

    A ratchet-like apical constriction drives cell ingression during the mouse gastrulation EMT

    Alexandre Francou, Kathryn V Anderson, Anna-Katerina Hadjantonakis
    High-resolution live and fixed tissue imaging combined with cell and tissue scale data analyses revealed that a ratchet-like constriction of the apical surfaces of cells drives the first step of an epithelial-to-mesenchymal transition taking place during mouse gastrulation.