Richard Panayiotou, Francesc Miralles ... Richard Treisman
G-actin binding controls the susceptibility of MRTF-A to phosphorylation, which works in concert with multiple NES elements to regulate MRTF-A subcellular localisation and activity.
Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
Convergent transcription and stalling of transcription are enriched at DNA breakpoints found in acute lymphoblastic leukemia and associate with DNA structures and sequences that mediate genetic instability.
Agustina D'Urso, Yoh-hei Takahashi ... Jason H Brickner
Epigenetic transcriptional memory employs a novel regulatory strategy to create a heritable poised state by remodeling and repurposing complexes involved in active transcription.
Emma Watson, Viridiana Olin-Sandoval ... Albertha JM Walhout
The roundworm C. elegans transcriptionally activates five genes comprising an alternate propionate breakdown pathway when dietary vitamin B12 is low or when the canonical pathway is compromised.
Rebecca Devlin, Catarina A Marques ... Richard McCulloch
Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
Yoshitaka Kawasoe, Toshiki Tsurimoto ... Tatsuro S Takahashi
Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.
