Yoshitaka Kawasoe, Toshiki Tsurimoto ... Tatsuro S Takahashi
Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.
Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
A telomerase recruitment mechanism delivers cell cycle information to the telomere-telomerase interface to ensure timely telomerase engagement at the telomere.
Quantitative super resolution imaging, in live mammalian cells, reveals a direct relationship between protein clustering dynamics and the number of mRNA transcribed at an endogenous gene locus.
The OSM-9 TRPV channel is differentially regulated due to developmental programming via modulation by TGF-β signaling, endogenous RNAi and chromatin remodeling pathways.
Activation of the integrated stress response by stalled translation elongation complexes attenuates neurodegeneration, and demonstrates a protective link between a decrease in the rate of translation initiation and defects in translation elongation.
PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.
Anton Goloborodko, Maxim V Imakaev ... Leonid Mirny
Loop extrusion can robustly compact, segregate and disentangle mammalian chromosomes, suggesting it is a universal mechanism of genome folding during cell division.
