Browse our latest Computational and Systems Biology articles

The emergent organization of bacterial proteomes—the integration of proteins into collective networks that encode function—can be defined purely from spectral analysis of ortholog covariation across extant diversity.

A smart combination of machine learning and high-throughput data generation of bacterial population dynamics successfully leads to an intriguing finding of the differentiation in decision-making components for bacterial growth.

A single-cell landscape of acral melanoma and the intermolecular regulatory relationships between microenvironments.

High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.

In the absence of COVID-19 mitigation measures, SARS-CoV-2 remains infectious for longer than previously estimated.

Visualizations, simulations, and examples are used to provide an accessible synthesis of the reasoning and assumptions behind commonly used causal discovery approaches.

Loss of nonstationary connectivity in a subcortical fronto-temporoparietal network distinguishes patients with minimal conscious state and unresponsive wakefulness state, strongly supporting the mesocircuit hypothesis.

Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.

A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.

Precisely tracking the anatomical sources of neural computations infers functional directed connectivity between hippocampal memory neurons and cortical sensory neurons, it reveals information flowing from cortex to hippocampus during encoding but the reverse direction during maintenance.