Browse our latest Computational and Systems Biology articles

Horizontal gene transfer between distantly related bacterial species is frequent and widespread and can be efficiently identified using alignment-free methods.

Ligand capture by cell surface receptor complexes sets the shape of the Nodal signaling pattern in zebrafish.

The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.

DNA concentration, cyclin levels, phosphatase activity, and CDK phosphorylation combine to directly link cell size to cell division.

Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.

The ability of the T cell receptor to discriminate ligands is imperfect, allowing T cells to respond to ultra-low-affinity ligands.

Modern machine learning methods offer new techniques for analyzing complex vocal behavior like ultrasonic mouse calls and birdsong.

Mathematical modeling and data analysis show that, over evolutionary times, the yeast temporal program of replication strives to avoid stalling events and minimize interference between neighbor origins.

Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.

Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.