Browse our latest Computational and Systems Biology articles

Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.

Chromosome replication and a different inter-division process both contribute to division control during unperturbed growth, but if division is delayed by increasing cell width the inter-division process becomes solely rate-limiting.

Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.

Accurate identification and quantification of various circRNA isoforms.

A parsimonious biophysical model correctly predicts the conserved expression stoichiometry of core bacterial mRNA translation factors, providing intuitive and quantitative design principles for in vivo pathway construction.

Comprehensive analysis of telomere maintenance from transcriptomic, epigenetic, and loss-of-function profiles of cancer cell lines elucidates features of telomere regulation in cancer.

Descriptions, examples, and tools to enable biologists to use the Common Workflow Language for data processing and to facilitate computational reproducibility.

With a data-driven mathematical modelling approach, within-host ecological information alone can provide clues on the mechanistic basis of diverse malaria infection outcomes.

Simple mathematical reasoning shows that the large amount of synaptic turnover seen in many parts of the brain is in fact optimal for memory retention.

Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.