Browse our latest Computational and Systems Biology articles

Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.

Modifying the recurrent connectivity of spiking networks provides sufficient flexibility to generate arbitrarily complex recurrent dynamics, suggesting that individual neurons in a recurrent network have the capability to support near universal dynamics.

A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.

Enriching the interactome with context-specific information from proteomics helps the identification of novel regulators of macrophage activation.

Integrating decades of small-scale experiments with human gene expression data provides a systems-level view of the coordinated molecular processes triggered by spinal cord injury, and their relationship to recovery.

An analysis of T cell receptor occurrence patterns that accounts for MHC restriction reveals striking imprints of common viral pathogens and patterns of TCR-HLA sequence covariation in a large human cohort.

In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.

A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.

How many copies of a protein can be made before it becomes toxic to the cell?

Measurement of expression limits of yeast glycolytic proteins reveal the protein burden limit, which is the expression limit of any protein in the cell.