Browse our latest Computational and Systems Biology articles

Pooled CRISPR knockout screening in Drosophila cells enables high-resolution, genome-wide functional genomic comparisons in cell-lines across vast evolutionary distance.

Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.

Tricellular vertices possess sliding behaviors that harness radial forces and drive cell shape changes and intercalation in an epithelial tissue.

Image-based motion correction enables the use of fluorescence lifetime and other functional imaging modalities in an intravital and clinical context in the presence of physiological motion.

A model reveals how translation of an mRNA leader could provide resistance to global downregulation of translation.

The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.

Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.

Metabolic division of labor in B. subtilis controls the extracellular environment.

The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.

A comprehensive approach to prediction of stabilizing mutations in G-protein coupled receptors yields high hit rate and crystal structures of 5HT2C in both active and inactive states.