Browse our latest Computational and Systems Biology articles

A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.

Crawling Drosophila larvae and C. elegans exhibit diffusive behavior alongside directed motion, and the dynamics of this navigation can be analyzed with techniques developed in understanding protein folding, using a Markov state model.

Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.

State-of-the-art computational methods have facilitated the construction of plant-based sentinels for detecting toxic molecules in the environment.

Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.

Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.

Sexual arousal in flies counteracts the effects of sleep deprivation.

A concerted approach employing equilibrium and biased molecular simulations, electrophysiology, mutagenesis, and functional assays reveals, in atomic details, the mechanism and pathway for transport of phospholipids and ions by a lipid scramblase.

To avoid internal traffic jams of nutrients that they absorb, plants need to swiftly regulate the transporters that take up those nutrients.

Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.