Computational and Systems Biology

Latest articles

1. 1. Neuroscience
   2. Computational and Systems Biology

   Decoding contextual influences on auditory perception from primary auditory cortex

   B. Englitz, S. Akram ... S. Shamma
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

   Lauren Kuffler, Daniel A Skelly ... Gregory W Carter

   Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.
3. 1. Computational and Systems Biology
   2. Developmental Biology

   A logic-incorporated gene regulatory network deciphers principles in cell fate decisions

   Gang Xue, Xiaoyi Zhang ... Zhiyuan Li

   A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.
4. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

   Ritwik Maity, Xuepei Zhang ... Javier Sancho
5. 1. Cell Biology
   2. Computational and Systems Biology

   De novo-designed minibinders expand the synthetic biology sensing repertoire

   Zara Y. Weinberg, Sarah S. Soliman ... Hana El-Samad
6. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Experimental evolution for the recovery of growth loss due to genome reduction

   Kenya Hitomi, Yoichiro Ishii, Bei-Wen Ying
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits

   Weichen Song, Yongyong Shi, Guan Ning Lin

   Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
8. 1. Computational and Systems Biology

   Genome-scale annotation of protein binding sites via language model and geometric deep learning

   Qianmu Yuan, Chong Tian, Yuedong Yang

   Integration of language model and geometric deep learning enables accurate and efficient genome-scale annotation of comprehensive protein-ligand binding sites.
9. 1. Neuroscience
   2. Computational and Systems Biology

   Deciphering the Genetic Code of Neuronal Type Connectivity: A Bilinear Modeling Approach

   Mu Qiao
10. 1. Computational and Systems Biology
    2. Physics of Living Systems

    The French flag problem revisited: Creating robust and tunable axial patterns without global signaling

    Stephan Kremser, Gabriel Vercelli, Ulrich Gerland