Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Computational and Systems Biology

    The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments

    Terence Li, Marcus Alvarez ... Noah Zaitlen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

    Natalia A Shevtsova, Andrew B Lockhart ... Simon M Danner
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

    David Saeb, Emma E Lietzke ... Kayla G Sprenger
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Computational and Systems Biology

    The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

    Lucas Fuentes Valenzuela, Paul Francois, Jan Skotheim
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

    András Ecker, Daniela Egas Santander ... Michael W Reimann
    A new framework for exploring the mechanisms underlying learning in cortical microcircuits is established.
    1. Computational and Systems Biology

    A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

    HaDi MaBouDi, Mark Roper ... James AR Marshall
    Active vision dynamically refines spatiotemporal neural representations, optimising visual processing through scanning behaviour and non-associative learning, providing insights into efficient sensory encoding in dynamic environments.
    1. Computational and Systems Biology

    Methylation: Modifying gene expression through passive forces

    Sarah Hallstein, Julian König
    The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
    Version of Record
    Insight
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    A quantitative model explains intra- and intercellular changes in m6A gene methylation as passive consequences of mRNA metabolism.
    1. Neuroscience
    2. Computational and Systems Biology

    Individuality transfer: Predicting human decision-making across tasks

    Hiroshi Higashi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete