Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

   Calvin M Schmidt, Christina D Smolke

   Machine learning has been applied to develop predictive models for designing RNA gene-control elements with targeted gene-regulatory activities.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Trading mental effort for confidence in the metacognitive control of value-based decision-making

   Douglas G Lee, Jean Daunizeau

   Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.
3. 1. Computational and Systems Biology
   2. Neuroscience

   Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

   Jack Goffinet et al.
4. 1. Computational and Systems Biology
   2. Developmental Biology

   Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

   Emanuel Cura Costa et al.
5. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

   Zachary Clemens et al.

   Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
6. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

   James W Opzoomer et al.

   ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
7. 1. Computational and Systems Biology
   2. Medicine

   Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

   Muhammad Arif et al.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

   Stephan Wilmes et al.

   IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
9. 1. Computational and Systems Biology

   A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

   Michael A Petr et al.

   A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
10. 1. Computational and Systems Biology
    2. Ecology

    TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

    Tristan Walter, Iain D Couzin

    Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.