The cortical collapse factor Efa6 limits axon growth and branching and maintains axonal microtubule bundle integrity by inhibiting microtubule polymerisation at the cell cortex.
Michael RM Harrison, Xidi Feng ... Ching-Ling Lien
Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
In vitro reprogramming of human fibroblasts to Sertoli-like cells with immunosuppressive properties provides platforms for basic research and clinical application.
Phenotypic evolution can originate from variations in very precocious developmental events, starting even before fecundation, during the fabrication of the egg in the mother's gonad.
Benjamin R Thomson, Isabel A Carota ... Susan E Quaggin
Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
Clara Sidor, Nerea Borreguero-Munoz ... Barry J Thompson
The MASK family of proteins regulate the action of the YAP/TAZ family of transcriptional coactivators, key regulators of stem cell proliferation and cancer.
Ayhan Atmanli, Dongjian Hu ... Ibrahim John Domian
A novel live-cell mRNA imaging technology identifies individual living cells based on their gene expression and enables the concurrent study of their physiology.