Browse our latest Developmental Biology articles

Page 136 of 209
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nephron progenitor commitment is a stochastic process influenced by cell migration

    Kynan T Lawlor, Luke Zappia ... Alexander N Combes
    Stochastic cell migration modulates exposure to signals that regulate commitment in the nephron progenitor niche.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush, Daniel C Diaz ... Tatjana Piotrowski
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Developmental Biology
    2. Neuroscience

    Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub

    Melissa A Borgen, Andrew C Giles ... Brock Grill
    Genetic, developmental and pharmacological analysis in Caenorhabditis elegans demonstrate that ATAT-2 tubulin acetyltransferase activity regulates synapse maintenance by acting within the RPM-1 signaling network, but independent of the DLK-1 MAP3K.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

    Vandita D Bhat, Kathleen L McCann ... Zachary T Campbell
    Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.
    1. Developmental Biology
    2. Neuroscience

    Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

    Ankita Ravi Vaswani, Beatrice Weykopf ... Sandra Blaess
    The first comprehensive insight into speed, trajectory and morphology profiles of tangentially migrating dopaminergic neurons and the alterations in their migratory behavior in absence of Reelin signaling.
    1. Developmental Biology

    Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

    Irepan Salvador-Martínez, Marco Grillo ... Maximilian J Telford
    Computer simulations reveal the potential and limitations of recently proposed CRISPR-based cell lineage recorders, and suggest how the recorders' design can be optimised to yield more accurate cell lineage trees.
    1. Developmental Biology

    Hedgehog signaling patterns the oral-aboral axis of the mandibular arch

    Jingyue Xu, Han Liu ... Rulang Jiang
    SHH signaling acts through FOXF1/2 transcription factors and antagonizes BMP signaling to specify oral fate and pattern the oral-aboral axis of the mandibular arch to ensure proper formation of jaws.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

    Mehdi Goudarzi, Kathryn Berg ... Alexander F Schier
    Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian, Lauren Fallon Kanzaki ... Thomas Friedrich Schilling
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Computational and Systems Biology
    2. Developmental Biology

    Cis-activation in the Notch signaling pathway

    Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz
    Activation of Notch receptors by ligands in the same cell (cis-activation) is a prevalent and functional mode of signaling in the Notch pathway, and co-exists with trans-activation and cis-inhibition.