Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
Mouse embryo cells undergo apical-basal polarization asynchronously at the 8-cell stage, and the timing of polarization influences subsequent lineage allocation.
Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.
A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
Eed, a core subunit of Polycomb repressive complex 2, is required for craniofacial osteoblast differentiation and mesenchymal proliferation after induction of the neural crest.
