Browse our latest Developmental Biology articles

Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.

The cellular behaviours that underlie the internalization of the multilayered endoderm anlage in Xenopus laevis link the ancestral mode of vertebrate gastrulation to common, epithelial-based mechanisms of gastrulation in non-vertebrate animals.

In the developing mouse, the regional distribution of neuronal apoptosis in the primary motor cortex and primary somatosensory cortex is controlled by sensory-driven and intrinsic electrical activity patterns.

Iodixanol supplementation provides a simple method for tuning the refractive index of live imaging media, which can greatly improve resolution and penetration depth in live imaging experiments.

Iodixanol provides an easy and affordable solution to a problem that has limited resolution and brightness when imaging living samples.

Calcium overload in cardiomyocytes disrupts sarcomere integrity, by stimulating transcriptional upregulation of the E3 ubiquitin ligase MuRF1.

PRDM13, a transcriptional repressor, antagonizes activity of basic-helix-loop-helix transcriptional activators and protects the developing spinal cord from aberrant expression of ventral-restricted cell-type regulators to generate the correct composition of neurons in the dorsal spinal cord.

In the spider Parasteatoda tepidariorum the transcription factor Ets4 is needed for cumulus integrity, dorsoventral patterning and for the activation of hunchback and twist expression.

Using Drosophila as a model organism shows that neural stem cell proliferation decisions in response to dietary nutrient conditions can be regulated by cell-autonomous lineage factors.

Global transcriptome changes, particularly alternative splicing, are highly dynamic the first 2 weeks after birth, and the example of calcineurin A splicing exemplifies the importance of alternative splicing during skeletal muscle development.