Laura González-Méndez, Irene Seijo-Barandiarán, Isabel Guerrero
Direct interaction between Hedgehog-sending and Hedgehog-receiving cytonemes is a fundamental mechanism for morphogen transfer and gradient establishment.
A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
Pablo Sanchez Bosch, Ruta Ziukaite ... Jean-Paul Vincent
Striped expression of Dpp in Drosophila wing precursors leads to graded signalling activity that positions wing veins and, in parallel, promotes growth in a gradient-independent manner by supplying signalling activity above a threshold.
A recent report proposing that the dpp stripe (the main source of the protein dpp) is dispensable for Drosophila wing disc growth missed the critical role on growth due to imprecise spatial removal of dpp.
Dpp emanating from the anterior-posterior compartment boundary is continuously required to promote proliferative growth of the whole fly wing appendage.
Genetic and cell biological study indicates that germ cells' connectivity serves as a mechanism to increase the sensitivity of germline to DNA damage, protecting the genome of gametes, in the Drosophila testis.
Daniel Andergassen, Christoph P Dotter ... Quanah J Hudson
Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.
Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
Cyrille Ramond, Nicolas Glaser ... Raphaël Scharfmann
A set of cell surface markers reconstruct human pancreatic differentiation and enable the segregation of pancreatic functions into specific populations.
