Browse our latest Developmental Biology articles

In a model of human neurulation (neuruloids), YAP is deferentially regulated across ecotodermal lineages, where it contributes to their differentiation and structural organization, and is hyper-active upon HD mutation, contributing to an HD-signature phenotype.

Combined lineage-tracing strategies, single-cell transcriptomic methods and in situ analyses identified mesodermal bipotent progenitors during craniofacial myogenesis that give rise to myogenic and connective tissues, thus redefining the lineage and evolutionary relationships between muscle and associated stroma.

Tissue-level cell tracking and analysis of actomyosin and N-cadherin adhesion dynamics, coupled with disruption of the regulatory gene Shroom3, reveals region-specific cell behaviors along the anteroposterior axis during neural tube closure.

A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.

Proline is essential for osteoblast differentiation and bone formation by facilitating the production of proline-enriched osteoblast proteins.

Intercellular communication is critical for organ function, and the role of innervation in mediating this communication is of relevance to many fields, including developmental biology, neuroendocrinology, and disease pathophysiology.

Wings achieve plasticity in size while maintaining robust pattern via ecdysone, which elicits graded responses for growth rates and threshold responses for patterning rates, in the fruit fly Drosophila melanogaster.

The immunoglobulin superfamily cell surface protein Sticks and Stones is a binding partner for the Lar Drosophila receptor tyrosine phosphatase that mediates Lar's developmental functions at the larval neuromuscular junction, mushroom body, and adult optic lobe.

BMP-dependent retinoic acid signaling is responsible for the separation of central from peripheral lineages during neural development.

Actin-related protein 5 antagonizes the interaction of Pbx/Meis with myogenic regulatory factors such as MyoD and MyoG, which is involved in the recruitment of the BRG1-based switch/sucrose nonfermentable chromatin remodeling complex required for myogenic gene activation.