Browse our latest Developmental Biology articles

Page 76 of 214
    1. Developmental Biology
    2. Physics of Living Systems

    Mechanism of life-long maintenance of neuron identity despite molecular fluctuations

    Joleen JH Traets, Servaas N van der Burght ... Jeroen S van Zon
    Differential binding kinetics of a master regulator to its target promoters can prevent spontaneous cell fate loss in a Caenorhabditis elegans neuron whose fate is controlled by a reversible switch.
    1. Developmental Biology

    Tracking cell lineages in 3D by incremental deep learning

    Ko Sugawara, Çağrı Çevrim, Michalis Averof
    Incremental deep learning enables accurate tracking of cell lineages in 3D with a modest investment in time and effort.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural control of growth and size in the axolotl limb regenerate

    Kaylee M Wells, Kristina Kelley ... Catherine D McCusker
    Signaling from the limb nerves regulates the rate of growth and the overall size of the regenerating limb.
    1. Developmental Biology

    Delilah, prospero, and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors

    Adel Avetisyan, Yael Glatt ... Adi Salzberg
    Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells.
    1. Developmental Biology
    2. Neuroscience

    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

    Eduardo Loureiro-Campos, António Mateus-Pinheiro ... Luísa Pinto
    Constitutive deficiency of AP2γ transcription factor impairs hippocampal glutamatergic neurogenesis and induces alterations on limbic-cortical connectivity that contribute to anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
    1. Computational and Systems Biology
    2. Developmental Biology

    Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

    Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
    The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: A matter of nerves

    Timothy J Duerr, James R Monaghan
    Regrowing new body parts requires neural input to restore appropriately sized limbs in salamanders.
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    Insight
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of sequentially generated septal neuron fates

    Miguel Turrero García, Sarah K Stegmann ... Corey C Harwell
    A combination of single-cell RNA sequencing of the developing septum and genetic fate mapping is used to analyze the origin of septal neurons.
    1. Developmental Biology

    Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach

    Ali Seleit, Alexander Aulehla, Alexandre Paix
    Highly efficient, precise, and scalable CRISPR/Cas9-mediated generation of endogenously tagged alleles in a vertebrate model.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

    Hourinaz Behesti, Arif Kocabas ... Mary E Hatten
    Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.