The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.
Konstantinos Gkatzis, Paolo Panza ... Didier YR Stainier
A serum-free organotypic culture model of mouse lung epithelial progenitors was developed and used to screen WNT modulators for regulators of epithelial differentiation.
Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.
Tom Dierschke, Eduardo Flores-Sandoval ... John L Bowman
The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.
Eduardo Pulgar, Cornelia Schwayer ... Miguel L Concha
Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site.
Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
