Joleen JH Traets, Servaas N van der Burght ... Jeroen S van Zon
Differential binding kinetics of a master regulator to its target promoters can prevent spontaneous cell fate loss in a Caenorhabditis elegans neuron whose fate is controlled by a reversible switch.
Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells.
Constitutive deficiency of AP2γ transcription factor impairs hippocampal glutamatergic neurogenesis and induces alterations on limbic-cortical connectivity that contribute to anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.
Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.
Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.