Browse our latest Developmental Biology articles

Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.

Using a cross-species phenotypic drug discovery pipeline, compounds promoting rod photoreceptor survival in zebrafish and mouse models of retinitis pigmentosa were identified, evidence of additive effects of paired compounds and inhibition of PARP-dependent cell death suggest novel therapeutic strategies.

Maternal loss of imprinting at the Igf2/H19 locus reduces expression of H19 lncRNA and thereby leads to progressive cardiac pathologies in a mouse Beckwith–Wiedemann syndrome model.

In the zebrafish relative Danio albolineatus, red erythrophores share a common progenitor with yellow xanthophores and require Cyp2ae2 and Bdh1a for accumulation of red ketocarotenoid pigment.

Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.

Neuronal circuits can be disrupted by ire-1-dependent mRNA decay to affect germline tumor cell identity by regulating cross-tissue communication in Caenorhabditis elegans.

Fluorescent perilipin zebrafish lines are powerful new tools for studying lipid droplet dynamics in health and disease.

The glypicans Dally-like protein and Dally reveal functional non-redundancy of the Hedgehog co-receptors Boi and Ihog through independent interactions and specifically regulate cytoneme dynamics via the Ihog FNIII domain, thus setting long-range signaling.

Non-centrosomal microtubule nucleation mediated by augmin is essential for neural progenitor mitosis and survival, and thus brain development.

The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.