Browse our latest Developmental Biology articles

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    1. Developmental Biology

    The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

    Yanyan Ding, Yuzhe Li ... Feng Liu
    A new zebrafish RBC aggregation model is developed to explore the dynamic process and the underlying regulatory mechanisms in blood clot formation.
    1. Developmental Biology
    2. Plant Biology

    Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways

    Jenia Schlegel, Gregoire Denay ... Rüdiger GW Simon
    Plant meristem size and shape is controlled by two intertwined regional feedback signals that are mediated by secreted peptides.
    1. Cell Biology
    2. Developmental Biology

    Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts

    Amrutha Kizhedathu, Piyush Chhajed ... Arjun Guha
    Reactive oxygen species can activate the ATR/Chk1 pathway in the absence of detectable DNA damage and without a requirement for DNA damage response proteins.
    1. Cell Biology
    2. Developmental Biology

    Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway

    Lianna W Wat, Zahid S Chowdhury ... Elizabeth J Rideout
    Drosophila females store more fat than males because the presence of a functional Transformer protein in females limits adipokinetic hormone production and pathway activity.
    1. Developmental Biology
    2. Neuroscience

    A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation

    Jie Wang, Amir Rattner, Jeremy Nathans
    Using single nucleus RNA sequencing, a complete catalogue of cell types was determined for the mouse iris, and this information was used as a starting point to define the effects of pupil dilation on gene expression and on nuclear morphology.
    1. Cell Biology
    2. Developmental Biology

    Ciliary Hedgehog signaling regulates cell survival to build the facial midline

    Shaun R Abrams, Jeremy F Reiter
    Genetic analysis identifies the origins of midface defects in mouse models of ciliopathies, revealing a role for ciliary Hedgehog signaling in cell survival.
    1. Developmental Biology

    mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia

    Soyeon Lim, You-Joung Kim ... Jin Woo Kim
    Comprehensive mouse genetic analyses show, by having mTORC1 constitutively active, a RPC divides and exhausts mitotic capacity faster than neighboring RPCs, and thus produces retinal cells that degenerate with aging-related changes in the mature mouse retina.
    1. Cell Biology
    2. Developmental Biology

    3D cell neighbour dynamics in growing pseudostratified epithelia

    Harold Fernando Gómez, Mathilde Sabine Dumond ... Dagmar Iber
    The 3D shape and dynamic organization of epithelial cells are far more complex than previously believed, but can be explained with simple physical principles based on lateral surface energy minimisation.
    1. Developmental Biology
    2. Genetics and Genomics

    Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

    Scott A Rankin, Jeffrey D Steimle ... Aaron M Zorn
    Epistatic analysis in Xenopus and mouse embryos reveals an evolutionarily conserved gene regulatory network downstream of the transcription factor Tbx5 and retinoic acid that coordinates cardiac and pulmonary development.
    1. Developmental Biology
    2. Medicine

    β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

    Shikai Hu, Jacquelyn O Russell ... Satdarshan P Monga
    Ductular reaction often observed in chronic liver pathologies such as in cystic fibrosis could be due to disruption of a novel complex of β-catenin-NF-κB and CFTR in cholangiocytes, which leads to persistent nuclear translocation of p65 and NF-κB activation.