Browse our latest Developmental Biology articles

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    1. Developmental Biology

    Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives

    Ezra Lencer, Rytis Prekeris, Kristin Bruk Artinger
    Pre-migratory and early migratory neural crest cells in zebrafish are transcriptionally diverse, with some cells expressing genes associated with differentiated derivatives while still in the neural tube.
    1. Cell Biology
    2. Developmental Biology

    Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection

    Parvathy Ramesh, Nidhi Sharma Dey ... Lolitika Mandal
    Ecdysone-mediated regulation of Relish expression and activation in the hematopoietic niche is essential for progenitor maintenance in the Drosophila Lymph gland.
    1. Developmental Biology
    2. Neuroscience

    Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

    Mizuki Kurashina, Jane Wang ... Kota Mizumoto
    Genetic analyses using a simple nervous system of the nematode revealed the novel function of the cell fate-determining transcriptional repressor complex in the differentiated neurons to determine the precise synapse position.
    1. Cell Biology
    2. Developmental Biology

    Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

    Federico Tessadori, Erika Tsingos ... Jeroen Bakkers
    The three-dimensional and asymmetrical transformations undergone by the zebrafish linear heart tube during looping morphogenesis are under the control of cardiac-intrinsic cues.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis

    Martin H Fabry, Federica A Falconio ... Gregory J Hannon
    Maternally deposited Piwi-piRNA complexes co-transcriptionally repress transposable elements that transiently become active in somatic cells of the developing Drosophila embryo.
    1. Cell Biology
    2. Developmental Biology

    SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

    Evelien Eenjes, Marjon Buscop-van Kempen ... Robbert J Rottier
    The balance between SOX2 and SOX21 is evolutionary conserved and is important for cell fate decision during lung epithelium development and repair after damage.
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani, Olivia Bay ... Kristin C Gunsalus
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Developmental Biology

    An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

    Zhaoyang Liu, Amro A Hussien ... Ryan S Gray
    The regulation of the biomechanical properties of tendons/ligaments is essential for the maintenance of spine alignment in the mouse.
    1. Developmental Biology
    2. Genetics and Genomics

    Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

    Yukiko Tando, Hitoshi Hiura ... Yasuhisa Matsui
    Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu, Jingjing Yu ... Xi Chen
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.