Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen
Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
Jason W Millington, George P Brownrigg ... Elizabeth J Rideout
The ability to adjust body size in response to diet is greater in Drosophila females than males because of a sex difference in the nutrient-dependent regulation of the insulin pathway.
Analysis of epigenome maps from human pancreatic progenitors and functional validation in zebrafish identify LAMA1 and CRB2 as type 2 diabetes risk-associated genes with roles in pancreatic development.
Sara N Stahley, Lena P Basta ... Danelle Devenport
Planar cell polarity protein Celsr1 clusters into punctate assemblies through lateral cis-interactions to function as an organizer of intercellular Frizzled6 and Vangl2 asymmetry.
Megan M Colonnetta, Lauren R Lym ... Girish Deshpande
A molecular duel between germline and somatic determinants ensures proper establishment of transcriptional quiescence in the primordial germ cells of early Drosophila embryos.
André Ferreira Castro, Lothar Baltruschat ... Hermann Cuntz
An optimal wire and function trade-off emerges from noisy growth and stochastic retraction during Drosophila class I ventral posterior dendritic arborisation (c1vpda) dendrite development.
Identification of heterogenous cranial neural crest (CNC)-derived cell populations and their roles in guiding craniofacial muscle development through cell-cell interactions.
The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
