Browse our latest Evolutionary Biology articles

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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

    Serkan Sayin, Brittany Rosener ... Amir Mitchell
    Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes

    Ching-Ho Chang, Isabel Mejia Natividad, Harmit S Malik
    Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals

    Evelyn Jagoda, Davide Marnetto ... Terence D Capellini
    Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Coordinated evolution at amino acid sites of SARS-CoV-2 spike

    Alexey Dmitrievich Neverov, Gennady Fedonin ... Georgii Bazykin
    Analysis of population diversity of SARS-CoV-2 revealed positive epistasis between sites carrying mutations characterizing rapidly expanding lineages.
    1. Cell Biology
    2. Evolutionary Biology

    Lifespan extension in female mice by early, transient exposure to adult female olfactory cues

    Michael Garratt, Ilkim Erturk ... Richard A Miller
    Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.
    1. Evolutionary Biology

    Microstructural and crystallographic evolution of palaeognath (Aves) eggshells

    Seung Choi, Mark E Hauber ... David J Varricchio
    The eggshells of palaeognath birds (e.g. ostrich, moa, kiwi, emu) have diverse homology and convergent features, and are useful modern analogues for the evolution of non-avian dinosaur eggshells.
    1. Developmental Biology
    2. Evolutionary Biology

    Vocal communication is tied to interpersonal arousal coupling in caregiver-infant dyads

    Sam Wass, Emily Phillips ... Louise Goupil
    Infants' vocalisations are contingent on their own stress physiology, and alter the inter-personal dynamics of how stress states are shared across the infant-caregiver dyad.
    1. Evolutionary Biology

    Adaptation dynamics between copy-number and point mutations

    Isabella Tomanek, Călin C Guet
    In bacteria, frequent adaptive copy-number mutations can hinder the fixation of beneficial point mutations and hence the divergence of duplicated DNA sequences.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.