Genes and Chromosomes

Latest articles

1. 1. Biochemistry
   2. Genes and Chromosomes

   In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing

   Beatriz A Osuna et al.

   Yeast extracts recapitulate a quality-control pathway dedicated to rescuing stalled ribosomes, providing unexpected insights into a noncanonical elongation reaction and the fate of incompletely synthesized proteins.
2. 1. Genes and Chromosomes
   2. Genomics and Evolutionary Biology

   Dynamics of genomic innovation in the unicellular ancestry of animals

   Xavier Grau-Bové et al.

   The foundations of genomic complexity in multicellular animals have deep roots in their unicellular prehistory, both in terms of innovations in gene content, as well as the evolutionary dynamics of genome architecture.
3. 1. Biophysics and Structural Biology
   2. Genes and Chromosomes

   A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

   Matthew Allan Sdano et al.
4. 1. Genes and Chromosomes

   Resolving the prevalence of somatic transposition in Drosophila

   Christoph D Treiber, Scott Waddell

   Current genome sequencing methods cannot reliably detect somatic transposition in Drosophila.
5. 1. Genes and Chromosomes
   2. Genomics and Evolutionary Biology

   Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

   Pierre Khoueiry et al.

   Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
6. 1. Genes and Chromosomes

   Maturation of selected human mitochondrial tRNAs requires deadenylation

   Sarah F Pearce et al.

   Removal of spurious poly(A) tails by the PDE12 exoribonuclease is required to maintain the integrity of human mitochondrial tRNAs and rRNAs and their availability for efficient mitochondrial translation.
7. 1. Genes and Chromosomes
   2. Genomics and Evolutionary Biology

   CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

   Adam D Norris et al.

   Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.
8. 1. Genes and Chromosomes

   A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

   Jonathan Strecker et al.
9. 1. Biophysics and Structural Biology
   2. Genes and Chromosomes

   Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

   Luis Miguel Diaz-Santin et al.
10. 1. Genes and Chromosomes

    Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

    Oscar Velazquez Camacho et al.

    An RNA-mediated mechanism that stabilizes association of the Suv39h enzymes at mouse heterochromatin is defined.