Genes and Chromosomes

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Decisions are made by journal editors who are active researchers interested in genes and chromosomes.

Latest articles

    1. Cell Biology
    2. Genes and Chromosomes

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    Research Article Updated
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    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Heredity: The gene family that cheats Mendel

    J Dylan Shropshire, Antonis Rokas
    Some alleles of the wtf gene family can increase their chances of spreading by using poisons to kill other alleles, and antidotes to save themselves.
    Insight
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    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    Research Article
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    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim et al
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
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    1. Genes and Chromosomes

    Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

    Oliver Willhoft et al
    Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the Ino80 subunit.
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    1. Biochemistry
    2. Genes and Chromosomes

    Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

    Davide Normanno et al
    In concert phosphorylation site modification of both XRCC4 and XLF C-terminal disordered tails promotes disassembly of XRCC4/XLF DNA tethers during c-NHEJ.
    Research Article Updated
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    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Enforcement of developmental lineage specificity by transcription factor Oct1

    Zuolian Shen et al
    Oct1 replaces Oct4 at critical targets shortly after ESC differentiation to promote expression of lineage-specific genes and repress lineage-inappropriate genes.
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    1. Cell Biology
    2. Genes and Chromosomes

    Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

    Jun Wan et al
    A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.
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    1. Genes and Chromosomes
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
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    1. Genes and Chromosomes

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    Research Article
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