Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression

    Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

    Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural mechanism of strand exchange by the RAD51 filament

    Luay Joudeh, Robert E Appleby ... Luca Pellegrini
    Not revised
    Reviewed Preprint v1
    • Landmark
    • Compelling
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    A technique that enables single-particle cryo-EM analysis of targets on a magnetic bead and a particle curation method that helps structural classification of small particles has been developed.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy

    Maciej A Kerlin, Ilham Aboulfath-Ladid ... Antoine Coulon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of ZDBF2

    Hisato Kobayashi, Tatsushi Igaki ... Kazuki Kurimoto
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

    Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells

    Benura Azeroglu, Wei Wu ... Eros Lazzerini Denchi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression

    Gene Regulation: Linking O-GlcNAc and intron retention

    John A Hanover
    An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Major nuclear locales define nuclear genome organization and function beyond A and B compartments

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.
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Highlights

    1. Chromosomes and Gene Expression

    Regulating intron detention

    John A Hanover
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager

Senior editors

  1. Silke Hauf
    Virginia Tech, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors