Genes and Chromosomes

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Decisions are made by journal editors who are active researchers interested in genes and chromosomes.
Illustration by Davide Bonazzi

Latest articles

    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk et al.
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

    Sarah N Deffit et al.
    Identification of tissue-specific RNA editing using a robust, publicly-available platform (SAILOR) reveals noncoding A-to-I editing events required for proper gene expression and neurological function, significantly advancing the understanding of how ADARs function in neural cells.
    1. Genes and Chromosomes

    Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

    Timothy W R Kelso et al.
    ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, and its homolog ARID1B function to maintain chromatin accessibility and active histone modifications at enhancers.
    1. Genes and Chromosomes

    Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth

    Zheng Kuang et al.
    General stress response factors Msn2 and Msn4 activate glycolytic genes and promote acetyl-CoA accumulation to stimulate growth and proliferation of yeast cells under a nutrient-limiting condition, suggesting the unexpected interrelationship between carbohydrate metabolism and stress response.
    1. Genes and Chromosomes
    2. Neuroscience

    Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

    Mattia Volta et al.
    LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
    1. Genes and Chromosomes
    2. Immunology

    Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

    Jaclyn E Quin et al.
    Examining gene expression in the Fulani, an ethnic group relatively protected from malaria, identifies a more transcriptionally reactive response in cells of the innate immune system.

Senior editors

  1. James Manley
    James Manley
    Senior Editor
  2. Jessica Tyler
    Jessica Tyler
    Senior Editor
  3. K VijayRaghavan
    K VijayRaghavan
    Senior Editor
  4. See more editors