Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Conserved and Unique Features of Terminal Telomeric Sequences in ALT-Positive Cancer Cells

    Benura Azeroglu, Wei Wu ... Eros Lazzerini Denchi
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A whole-organism landscape of X-inactivation in humans

    Bjorn Gylemo, Maike Bensberg, Colm E Nestor
    Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity

    Tony KY Lim, Anne Ritoux ... Ewan St. John Smith
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Real-time transcriptomic profiling in distinct experimental conditions

    Tamer Butto, Stefan Pastore ... Susanne Gerber
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural mechanism of strand exchange by the RAD51 filament

    Luay Joudeh, Robert E Appleby ... Luca Pellegrini
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Compelling
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Molecular Landscape of the Mouse Adrenal Gland and Adjacent Adipose by Spatial Transcriptomics

    Małgorzata Blatkiewicz, Szymon Hryhorowicz ... Marcin Rucinski
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

    Siqi Wang, Danyue Dong ... Zefeng Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Drosophila hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ADMA-histones play a crucial role in the initial recognition of dual-strand piRNA cluster regions by Rhino

    Raku Saito, Hirotsugu Ishizu ... Mikiko C Siomi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Highlights

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager
    1. Chromosomes and Gene Expression

    Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors