Browse our latest Genetics and Genomics articles

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    1. Evolutionary Biology
    2. Genetics and Genomics

    Plants: Re-evaluating the driving force behind mutations

    Thibault Leroy
    Experiments on tropical trees suggest that new mutations in plants are driven by age rather than number of cell divisions during growth.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera)

    Joseph S Latshaw, Reece E Mazade ... Brian Smith
    Genetic variation in a biogenic amines receptor underlies a means of gain control for nonassociative learning and hence an important form of attention that is the basis for tradeoffs in foraging in a social collective.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

    Ekaterina S. Maksimova, Sven E. Ojavee ... Matthew R. Robinson
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    John F Ouyang, Kunal Mishra ... Jacques Behmoaras
    A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1+ macrophages in multiple human fibrotic tissues.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Broad functional profiling of fission yeast proteins using phenomics and machine learning

    María Rodríguez-López, Nicola Bordin ... Jürg Bähler
    Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.
    1. Cell Biology
    2. Genetics and Genomics

    Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations

    Christopher H Emfinger, Lauren E Clark ... Alan D Attie
    Analysis of islet calcium oscillation responses will provide the field with a resource with which to determine the strain of interest for their specific islet biology questions.
    1. Cell Biology
    2. Genetics and Genomics

    Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

    Sagen Flowers, Rushali Kothari ... Joel H Rothman
    Mitochondrial quality control in the germline is mediated by regulators of both programmed cell death and the aging program.
    1. Genetics and Genomics
    2. Neuroscience

    Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

    Yoshifumi Sonobe, Soojin Lee ... Paschalis Kratsios
    Mutational analysis in cell-based models of C9ORF72 ALS/FTD identifies canonical translation initiation codons (AUG) on the antisense CCCCGG transcript as initiation sites for synthesis of neurotoxic dipeptide repeat proteins.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci
    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Effects of smoking on genome-wide DNA methylation profiles: A study of discordant and concordant monozygotic twin pairs

    Jenny van Dongen, Gonneke Willemsen ... Michael C Neale
    Analysis of data from monozygotic twins reveals that DNA methylation level in human blood cells is reactive to cigarette smoking.