The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
Sumedha Dahal, Humaira Siddiqua ... Sathees C Raghavan
A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.
Benjamin J Chadwick, Tuyetnhu Pham ... Xiaorong Lin
In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO2.
A type 2 diabetes polygenic risk score and family history of diabetes are strongly and independently associated with multiple gestational diabetes-related traits in women of South Asian descent.
A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.
R-spondin3 global haplo-insufficiency or its deletion in pre-osteoblasts lead to gain of bone mass in the appendicular skeleton with no or opposite phenotype in the axial skeleton.
