Browse our latest Genetics and Genomics articles

An electrophysiology-based genetic screen in Drosophila identified a role for the E3 ligase Thin in presynaptic homeostatic plasticity.

A novel form of self-fertility evolved in Cryptococcus depauperatus, a close relative to the human pathogenic Cryptococcus species, in which sexual development is attained by self-signaling of a cognate pheromone and pheromone-receptor pair.

Genetic variation influencing the gut microbiome is abundant among incipient mammalian host species, and cospeciating bacterial taxa display a unique genetic architecture.

Development of a genomic dating method that leverages ancestry covariance patterns in a single diploid individual reveals the timing of major admixture events during the European Holocene.

Genetic effects on body weight in mice are highly heterogeneous, dynamic, and nonlinear with respect to genomic background, age, and diet.

The diet and age of mice can modulate how different genetic variants impact body weight, demonstrating the need to take context into account when performing genetic studies.

Opposing activities of ATR kinase and PP4 phosphatase balance phosphorylation of the protein DSB-1 to produce sufficient but not excessive amount of DNA double-strand breaks during meiotic prophase in Caenorhabditis elegans.

By measuring the impacts of thousands of mutations on potassium channel trafficking and function, we illuminate the molecular basis of folding, structure–function relationships, and how these are altered in disease.

Both human and microbe cell-free RNA features in plasma could distinguish tumors of different primary locations.

Analyses of spindle genes with missense changes in modern humans reveal evidence for positive selection since the split with archaic humans and show that modern humans interacted with Neandertals more than once in the past 200,000 years.