Browse our latest Human Biology and Medicine articles

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    1. Developmental Biology
    2. Human Biology and Medicine

    Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

    Benjamin R Thomson et al.
    Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
    1. Human Biology and Medicine

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

    Mark S Ladinsky et al.
    Large-volume light microscopy combined with higher-resolution electron tomography revealed the spatial distribution of virus-producing cells and highlighted mechanisms of HIV-1 dissemination in bone marrow from a small animal model.
    1. Cell Biology
    2. Human Biology and Medicine

    Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

    Prashant Rajbhandari et al.
    Crosstalk between IL10-producing immune cells and adipocytes within adipose tissue is an important determinant of thermogenesis and systemic energy balance.
    1. Epidemiology and Global Health
    2. Human Biology and Medicine

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

    Jingwei Zeng et al.
    Studying the impact of natural variation on a key immune gene highlights how focusing on a single wild-type sequence overlooks that rare variants cause the most disease.
    1. Human Biology and Medicine

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.