Browse our latest Human Biology and Medicine articles

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    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

    David J Goldhamer, John B Lees-Shepard
    We respond to concerns expressed by Pacifici and Shore (2019) about our recent paper (Lees-Shepard et al., 2018a).
    1. Human Biology and Medicine

    Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

    Maurizio Pacifici, Eileen M Shore
    We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018).
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Meta-Research: Gender inequalities among authors who contributed equally

    Nichole A Broderick, Arturo Casadevall
    An analysis of papers in which two or more authors shared first-author position found that male authors were more likely than female authors to appear first in the author list.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan et al.
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota density influences host physiology and is shaped by host and microbial factors

    Eduardo J Contijoch et al.
    The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.
    1. Human Biology and Medicine

    Meta-Research: Why we need to report more than 'Data were Analyzed by t-tests or ANOVA'

    Tracey L Weissgerber et al.
    Many papers in basic biomedical science do not contain the information that is needed to determine what statistical tests were used and to verify the results of these tests.
    1. Human Biology and Medicine

    Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

    Matthew Hancock et al.
    Cardiomyocyte Nox4 is a crucial physiological mediator of Nrf2 activation during acute exercise, triggering an adaptive response that preserves redox balance, mitochondrial and cardiac function to support normal physical exercise.
    1. Human Biology and Medicine

    Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

    Yael Riahi et al.
    mTORC1 inhibition by perinatal ER stress induces beta-cell growth arrest with subsequent development of diabetes.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Insulin: Folding mutations suppress early beta-cell proliferation

    Honey Modi, James D Johnson
    Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
    Insight
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    1. Cell Biology
    2. Human Biology and Medicine

    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

    Martina Rudnicki et al.
    Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.