Browse our latest Immunology and Inflammation articles

Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.

Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.

Bioinformatics analyses and experiments in mouse models reveal how Escherichia coli accesses the molecular hydrogen pool to boost colonization during acute colitis.

Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.

Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.

Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.

The needs and challenges of AIRR-seq controls are presented.

Spliced peptides present on tumor cells can help to mount an immune response, but algorithms offer limited help in predicting which ones actually exist and perform this role in vivo.

At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.

Genetic and molecular characterization showed that evolutionarily conserved flavin-containing monooxygenase (FMO-2) plays an important role in host defense in Caenorhabditis elegans, and its induction is dependent on conserved transcription factors, TFEB and PPAR-α.