The transparent zebrafish reveals the reality of trypanosomes swimming in a vertebrate host, and their adaptations to an extremely heterogenic environment.
Ashley M Ngo, Matthew J Shurtleff ... Andreas S Puschnik
The ER membrane protein complex (EMC) facilitates the correct topology of the flavivirus non-structural proteins NS4A and NS4B at the ER membrane critical for viral replication.
Charles F Ericson, Fabian Eisenstein ... Nicholas J Shikuma
Bacteria produce a syringe-like structure, loaded with a single protein within the lumen of its needle-like tube, that is sufficient for stimulating animal metamorphosis.
Isabella Vlisidou, Alexia Hapeshi ... Nicholas R Waterfield
The insect pathogenic bacterium Photorhabdus has evolved astonishing nano-scale analogues of hypodermic syringes that it uses to inject toxins into host cells.
A key cellular stress granule protein, G3BP1, is critical for efficient norovirus infection, representing the first pan-norovirus, pro-viral factor identified to date.
Michael R McLaren, Amy D Willis, Benjamin J Callahan
A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
Kevin J Forsberg, Ishan V Bhatt ... Harmit S Malik
A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.