Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

    Ethan S FitzGerald, Amanda M Jamieson
    We are writing to comment on an article by Mast et al., 2021, about the drivers of coagulopathy in the lungs of COVID-19 patients.
    1. Microbiology and Infectious Disease

    Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

    Lisanne de Vor, Bruce van Dijk ... Suzan HM Rooijakkers
    Antibody-based biologicals could provide an alternative approach to improve the diagnosis of Staphylococcus aureus biofilm-related infections.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum

    Ning Zhang, Limin Song ... Wenxing Liang
    The decrotonylase FoSir5 modulates ATP synthesis that supports conidial germination in Fusarium oxysporum through coordinated lysine decrotonylation in different organelles.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Distinguishing different modes of growth using single-cell data

    Prathitha Kar, Sriram Tiruvadi-Krishnan ... Ariel Amir
    Single-cell data analysis must be guided by an underlying model.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Pan-genome analysis identifies intersecting roles for Pseudomonas specialized metabolites in potato pathogen inhibition

    Alba Pacheco-Moreno, Francesca L Stefanato ... Andrew W Truman
    Genomics and genetics were used to identify specialized metabolites employed by Pseudomonas bacteria to suppress the growth of potato pathogens, which revealed a key role for cyclic lipopeptides.
    1. Microbiology and Infectious Disease

    Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

    Pedro Escoll, Lucien Platon ... Carmen Buchrieser
    During infection, L. pneumophila reverses the ATP-synthase activity of the mitochondrial FOF1-ATPase to ATP-hydrolase activity in a type 4 secretion-dependent manner to prevent early cell death, thereby preserving its replication niche.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

    Gabriela C Olivera, Emily C Ross ... Antonio Barragan
    The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
    1. Microbiology and Infectious Disease

    The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

    Jennifer E Dumaine, Adam Sateriale ... Boris Striepen
    Following initial invasion events, intracellular life stages of C. parvum rely upon an N-terminal host-targeting motif and proteolytic processing at a specific leucine residue to deliver proteins into the infected enterocyte.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A bacterial membrane sculpting protein with BAR domain-like activity

    Daniel A Phillips, Lori A Zacharoff ... Sarah M Glaven
    Uniform diameter and curvature of the outer membrane extensions and vesicles of Shewanella oneidensis are maintained by a bacterial Bin/Amphiphysin/Rvs (BAR) domain-like protein BdpA.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

    Sarah Lauren Svensson, Cynthia Mira Sharma
    Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.