Browse our latest Microbiology and Infectious Disease articles

The local fitness landscape of an antigenic region in influenza neuraminidase was determined by combinatorial mutagenesis and next-generation sequencing.

HIV infection increases SARS-CoV-2 disease severity and alters immune cell dynamics in a beta variant dominated infection wave.

Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca²⁺ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.

A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.

A new protocol step improves robustness and ease-of-use for mass spectrometry in the clinic, opening the door to mass deployment to monitor infectious agents.

A gaseous signaling molecule hydrogen sulfide stimulates mitochondrial bioenergetics, maintains glutathione redox poise, and suppresses ROS to subvert viral rebound in latently infected CD4⁺ T cells from HIV subjects.

A large repertoire of nanobodies that target discrete regions of SARS-CoV-2 spike shows effective neutralization against variants of concern with many pairwise combinations resistant to escape and demonstrating synergistic neutralization activities.

Bacterial gut pathogens that invade into host tissues during infection can boost the spread and accumulation of plasmids over time by forming reservoirs containing these plasmids within host tissues.

Regulation of a nuclear receptor signaling pathway may cure the often-lethal disease caused by the endemic parasitic roundworm, Strongyloides stercoralis.

A new tick metabolic pathway that is connected to the survival of the Lyme disease spirochete was identified, which may lead to new ways to interfere with the spirochete life cycle.