Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections

    Marissa Jeme Andersen, ChunKi Fong ... Ana L Flores-Mireles
    The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

    David W Hawman, Kimberly Meade-White ... Jesse H Erasmus
    A replicating RNA vaccine platform generated significant immunity against SARS-CoV2 in mice and hamsters, and can be updated to target variants of concern.
    1. Microbiology and Infectious Disease

    Recognition of discrete export signals in early flagellar subunits during bacterial type III secretion

    Owain J Bryant, Paraminder Dhillon ... Gillian M Fraser
    Proteins for bacterial flagella biogenesis contain two discrete export signals, recognised sequentially by the flagellar Type III Secretion System to facilitate initial docking and subsequent opening of the export gate.
    1. Ecology
    2. Microbiology and Infectious Disease

    Noisy metabolism can promote microbial cross-feeding

    Jaime G Lopez, Ned S Wingreen
    Noise-averaging cooperation (NAC) is a novel theory for the emergence of microbial cross-feeding by which noisy intracellular metabolism can promote cooperation and cross-feeding among cells.
    1. Microbiology and Infectious Disease

    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

    Myriam Scherer, Clarissa Read ... Thomas Stamminger
    Characterization of PML subnuclear structures during human cytomegalovirus infection demonstrates that prolonged interferon and DNA damage signaling can induce giant PML nuclear bodies which sequentially entrap both nucleic acids and viral proteins as a cytoprotective mechanism.
    1. Medicine
    2. Microbiology and Infectious Disease
    3. Epidemiology and Global Health
    4. Immunology and Inflammation
    Covid-19. Translational and Clinical Research

    Infectious Diseases: A Collection of Translational and Clinical Research Articles

    Edited by Bavesh Kana et al.
    eLife has published articles on a wide range of infectious diseases, including COVID-19, influenza, tuberculosis, HIV/AIDS, malaria and typhoid fever.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

    Marco A Díaz-Salinas, Qi Li ... James B Munro
    The function of the SARS-CoV-2 spike is controlled by allosterically modulating the dynamics of the receptor-binding domain.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

    Vivian Vasconcelos Costa, Michelle A Sugimoto ... Mauro Martins Teixeira
    An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

    Justin YA Doritchamou, Jonathan P Renn ... Patrick E Duffy
    VAR2CSA, the leading candidate antigen for a placental malaria vaccine, displays epitopes targeted by naturally acquired broadly neutralizing antibodies of African multigravidae.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

    Megan Okada, Krithika Rajaram ... Paul A Sigala
    Malaria parasites target a polyprenyl synthase enzyme to the apicoplast organelle and require its activity to produce long-chain linear isoprenoids necessary for apicoplast biogenesis.
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