Browse our latest Microbiology and Infectious Disease articles

Page 90 of 168
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham, Kacie L McCarty, Philip J Kranzusch
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang, Thomas A Hughes ... Sriram Neelamegham
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Amol K Bhandage, Gabriela C Olivera ... Antonio Barragan
    Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Meta-Research: COVID-19 research risks ignoring important host genes due to pre-established research patterns

    Thomas Stoeger, Luís A Nunes Amaral
    An analysis of 10,395 research publications about COVID-19 that mention at least one human gene reveals that many genes implicated in SARS-CoV-2 infection by genome-wide studies remain unstudied.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott, Jenna E Eschbach ... Sebla B Kutluay
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Microbiology and Infectious Disease

    Viral Maturation: How to package the RNA of HIV-1

    Alex Kleinpeter, Eric O Freed
    Interactions between viral RNA and the integrase enzyme are required for HIV-1 particles to become infectious, a process that can be disrupted through multiple mechanisms.
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    Insight
    1. Microbiology and Infectious Disease

    Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

    Megan Okada, Ping Guo ... Paul A Sigala
    Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.
    1. Microbiology and Infectious Disease

    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

    Shuxin Liu, Jiwei Luo ... Zhao-Qing Luo
    A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
    1. Microbiology and Infectious Disease

    The alternative sigma factor σX mediates competence shut-off at the cell pole in Streptococcus pneumoniae

    Calum HG Johnston, Anne-Lise Soulet ... Patrice Polard
    Tracking fluorescent fusion proteins in competent pneumococcal cells reveals a polar hub for competence regulation, with the alternative sigma factor σX relocalizing DprA to this hub to mediate competence shut-off.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transcription termination and antitermination of bacterial CRISPR arrays

    Anne M Stringer, Gabriele Baniulyte ... Joseph T Wade
    Many bacteria use the Nus factor antitermination complex to prevent premature Rho-dependent transcription termination of their CRISPR arrays.