Jonathan S Schor, Isabelle Gonzalez Montalvo ... Alexandra B Nelson
In a mouse model of Parkinson's disease, deep brain stimulation of the subthalamic nucleus disrupts movement-related neural activity in parallel with relieving motor symptoms.
Label-free three-photon imaging of whole, uncleared intact organoids generated from Rett syndrome patients show shorter migration distances and slower migration speeds of mutant radially migrating neurons with more tortuous trajectories.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
Excitation of contralesional cortex after stroke suppresses the expression of genes related to plastic neuronal reintegration and accordingly modulates perilesional remodeling and functional network communication at local and global scales.
Samantha S Cohen, Nim Tottenham, Christopher Baldassano
Brain responses to a narrative movie change over the course of childhood and adolescence, shifting from event-boundary responses in the hippocampus to stable and anticipatory event representations in the neocortex.
In teleost fishes, the independent evolution of electrosensory systems was repeatedly associated with evolutionary changes in brain region scaling that were independent of changes in brain–body allometry.
Allison T Goldstein, Terrence R Stanford, Emilio Salinas
The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
Chronic inhibition of mTORC1 signaling strongly affects the morphology, physiology and output of dopamine neurons leading to impaired dopaminergic function in mice.
Regulation of Cav2.3 Ca2+ channels by membrane-bound β2 subunit splice variants permits long-lasting channel activity even during prolonged and continuous activity in dopamine neurons, with implications for Parkinson's disease pathophysiology.
