Browse our latest Physics of Living Systems articles

Page 39 of 54
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers

    Marco Molari, Klaus Eyer ... Rémi Monasson
    Detailed and inferred model reproduces B-cell affinity distributions measured in mice immunized according to various protocols and explains non-monotonous effects of antigen dosage on maturation.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Phase Separation: Restricting the sizes of condensates

    Furqan Dar, Rohit Pappu
    Computer simulations of model proteins with sticker-and-spacer architectures shed light on the formation of biomolecular condensates in cells.
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    Insight
    1. Cell Biology
    2. Physics of Living Systems

    The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

    Akanksha Thawani, Michael J Rale ... Sabine Petry
    Four αβ-tubulin dimers associate laterally on γ-TuRC to define the rate-limiting transition state for microtubule nucleation.
    1. Neuroscience
    2. Physics of Living Systems

    Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

    Joanne C Gordon, Natalie C Holt ... Monica A Daley
    Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
    1. Ecology
    2. Physics of Living Systems

    Ant collective cognition allows for efficient navigation through disordered environments

    Aviram Gelblum, Ehud Fonio ... Ofer Feinerman
    When real ants confront the classical 'Ant-in-a-labyrinth' physics problem where a random walker traverses a percolated environment, they employ active extended sensing and collective cognition to outperform passive physical solutions.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

    Rupamanjari Majumder, Tim De Coster ... Daniël A Pijnappels
    Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Nuclei determine the spatial origin of mitotic waves

    Felix E Nolet, Alexandra Vandervelde ... Lendert Gelens
    Nuclei and spatial system dimensions control local concentrations of cell cycle regulators, determining the spatial origin of waves that coordinate​ DNA replication and, subsequently, cell division.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan, Aafke A van den Berg ... Leonid A Mirny
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert, Peng Gao ... Gerd Ulrich Nienhaus
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.