Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

    Rachel Lander, Christian P Petersen
    Signaling molecules expressed in overlapping body-wide transcriptional gradients determine central axis positional identity in whole-body regeneration.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Adult axolotls can regenerate original neuronal diversity in response to brain injury

    Ryoji Amamoto, Violeta Gisselle Lopez Huerta ... Paola Arlotta
    Upon injury, the regeneration of the adult axolotl brain rebuilds neuronal diversity, but alters the original long-distance circuitry and tissue architecture.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division

    Lihua Wang, Pengcheng Bu ... Xiling Shen
    A novel long non-coding RNA targets microRNA miR-34a for epigenetic silencing and initiates asymmetric division of colon cancer stem cells.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers, Sailaja Peddada ... Barbara Panning
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Stem cell progeny contribute to the schistosome host-parasite interface

    James J Collins III, George R Wendt ... Phillip A Newmark
    Stem cells are found to continually rejuvenate the epidermis of the human parasite Schistosoma mansoni.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs

    Robin E Harris, Linda Setiawan ... Iswar K Hariharan
    Localized silencing of damage-responsive enhancers can block regenerative growth while permitting those same genes to be used for normal development.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

    Marius Walter, Aurélie Teissandier ... Déborah Bourc'his
    The various transposon families of the mammalian genome can adopt different types of repressive chromatin responses upon DNA methylation loss.
    1. Stem Cells and Regenerative Medicine

    Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle

    Zijian Xu, Wenjie Wang ... Ting Chen
    Long-term hair follicle stem cells arise by embryonic progenitor cells occupying a niche location that is defined by attenuated Wnt/β-catenin signal.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

    Aida Rodrigo Albors, Akira Tazaki ... Elly M Tanaka
    During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.