Browse our latest Structural Biology and Molecular Biophysics articles

The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.

The cryo-EM structures of XKR9 define the architecture and caspase-mediated activation of a protein family that is involved in the exposure of phosphatidylserine during apoptosis leading to the engulfment of apoptotic cells by macrophages.

Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.

The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.

First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.

The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.

The novel cryo-electron microscopy structure of a bacterial protein-only RNase P illustrates how a small protein oligomerizes into a dodecameric assembly to catalyze the 5’-end maturation of tRNAs.

Small Rho GTPases confer up- and downregulation in mammalian plexin signaling by differential interactions with cell membrane.

2D template matching complements 3D template matching of tomograms, providing fast and specific detection of molecules in cryo-EM images of cells, as well as generating 3D reconstructions from detected targets.

During sporulation, FtsAZ filaments mediating cell division in Bacillus subtilis are positioned asymmetrically around the septum only on the mother cell side, making the septum thinner than during vegetative growth.