Browse our latest Structural Biology and Molecular Biophysics articles

The volatile anesthetic isoflurane directly binds to the transmembrane domains of the TREK1 channel to allosterically modulate its function.

Structural and biochemical data suggest a mechanism for the Synaptojanin1-catalysed reaction and the role of mutations in the onset of associated neurological diseases.

A detailed molecular mechanism on lipid flipping from outside leaflet to the inside leaflet of the eukaryotic plasma membrane bilayer.

The MIR domain of protein-O-mannosyltransferases participates in glycosylation by binding mannosylated peptides and regulates enzyme processivity.

A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.

An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.

Integral membrane subunits of energy-coupling factor transporters associate with and dissociate from each other as part of the transport mechanism.

Cryo-electron microscopy reveals how kinesin-binding protein inhibits microtubule attachment in a subset of kinesins.

The disordered C-terminal tail allows XRCC4-like factor (XLF) to find and bind the XRCC4-Lig4 complex, enabling DNA end synapsis and subsequent ligation during non-homologous end joining.

The THO-Sub2 complex is an asymmetric homodimer that uses the spatial arrangement of two Sub2 helicases to prevent RNA:DNA hybrids.